Our goal is the discovery and development of entirely new classes of antibiotics capable of selectively targeting and killing bacterial cells via novel modes of action. To do so we apply a strategy aimed at identifying compounds capable of binding lipid II, the unique molecular building block of the bacterial cell wall. Importantly, lipid II has no known role in human metabolism but is essential to bacterial growth and survival. To date we have successfully discovered a number of new compounds that kill bacterial cells via lipid II-dependant mechanisms. Ongoing work is aimed at optimizing the activity of these lead compounds for development as new first-in-class antibiotics.